For research use only. Not for therapeutic Use.
Cbz-NH-PEG3-CH2COOH(CAT: I016192) is a valuable PEG-based linker essential for the synthesis of PROTAC molecules. This linker acts as a bridge between the target-binding ligand and the E3 ligase ligand within the PROTAC structure. The polyethylene glycol (PEG) moiety offers enhanced solubility, biocompatibility, and cellular permeability, facilitating effective intracellular delivery. The strategic incorporation of Cbz protecting group ensures controlled manipulation of the amino group, enabling precise conjugation in the synthesis process.
| Catalog Number | I016192 |
| CAS Number | 462100-05-6 |
| Molecular Formula | C₁₆H₂₃NO₇ |
| Purity | ≥95% |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
