Cbz-NH-PEG4-C2-acid

• CAT Number: I015623
• CAS Number: 756526-00-8
• Molecular Formula: C₁₉H₂₉NO₈
• Molecular Weight: 399.44
• Purity: ≥95%
• Target: PROTAC Linkers

Cbz-NH-PEG4-C2-acid(CAT: I015623) is a polyethylene glycol (PEG)-based PROTAC linker designed for use in the synthesis of PROTAC molecules. PROTACs (PROteolysis TAgeting Chimeras) are innovative therapeutic agents that exploit the ubiquitin-proteasome system to selectively degrade target proteins within cells. This linker provides a versatile and customizable bridge between the ligand for the target protein and the ligand for an E3 ubiquitin ligase, enabling the recruitment of the target protein to the proteasome for degradation.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562