Cbz-Phe-(Alloc)Lys-PAB-PNP

• CAT Number: I017814
• CAS Number: 159857-90-6
• Molecular Formula: C₄₁H₄₃N₅O₁₁
• Molecular Weight: 781.81
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: [4-[[(2S)-1-amino-1-oxo-6-(prop-2-enoxycarbonylamino)hexan-2-yl]-[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C41H43N5O11/c1-2-25-54-39(49)43-24-10-9-15-36(37(42)47)45(32-18-16-31(17-19-32)28-56-41(51)57-34-22-20-33(21-23-34)46(52)53)38(48)35(26-29-11-5-3-6-12-29)44-40(50)55-27-30-13-7-4-8-14-30/h2-8,11-14,16-23,35-36H,1,9-10,15,24-28H2,(H2,42,47)(H,43,49)(H,44,50)/t35-,36-/m0/s1
• InChIKey: ZDMMWLUQPVUZQI-ZPGRZCPFSA-N
• SMILES: C=CCOC(=O)NCCCC[C@@H](C(=O)N)N(C1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])C(=O)[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4

Cbz-Phe-(Alloc)Lys-PAB-PNP(CAT: I017814) is a chemically synthesized linker widely utilized in prodrug design and enzyme-mediated drug release research. It incorporates a Cbz-protected phenylalanine (Cbz-Phe) and an allyloxycarbonyl-protected lysine (AllocLys) moiety, connected via a para-aminobenzyloxy (PAB) spacer to a para-nitrophenyl (PNP) group. This structure enables targeted drug activation through enzymatic cleavage, releasing bioactive compounds in a controlled manner. Researchers use Cbz-Phe-(Alloc)Lys-PAB-PNP to study site-specific drug delivery mechanisms, particularly in the context of cancer and enzyme-targeted therapies. Its versatility and precision make it an essential tool in advancing drug discovery and developing innovative therapeutic strategies.