CC-11050

For research use only. Not for therapeutic Use.

  • CAT Number: I024223
  • CAS Number: 340019-69-4
  • Molecular Formula: C24H28N2O6S
  • Molecular Weight: 472.55
  • Purity: 98%
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CC-11050(Cat No.:I024223) is a bioactive chemical compound that exhibits biological activity or functionality. However, without additional specific information about CC-11050, it is challenging to provide a comprehensive description. Bioactive chemicals can have diverse effects, such as modulating enzyme activity, influencing cellular processes, or interacting with biological targets.


Catalog Number I024223
CAS Number 340019-69-4
Synonyms

CC-11050; CC 11050; CC11050

Molecular Formula C24H28N2O6S
Purity 98%
Target Phosphodiesterase (PDE)
Solubility Soluble in DMSO
Appearance Solid powder
Storage 4°C, away from moisture and light
IUPAC Name Cyclopropanecarboxamide, N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-3-oxo-1H-isoindol-4-yl)-
InChI InChI=1S/C24H28N2O6S/c1-4-32-21-12-16(10-11-20(21)31-2)19(14-33(3,29)30)26-13-17-6-5-7-18(22(17)24(26)28)25-23(27)15-8-9-15/h5-7,10-12,15,19H,4,8-9,13-14H2,1-3H3,(H,25,27)/t19-/m1/s1
InChIKey QDZOBXFRIVOQBR-LJQANCHMSA-N
SMILES O=C(C1CC1)NC2=CC=CC(CN3[C@@H](C4=CC=C(OC)C(OCC)=C4)CS(=O)(C)=O)=C2C3=O
Reference

1: Boulougoura A, Gabriel E, Laidlaw E, Khetani V, Arakawa K, Higgins J, Rupert A, Gorelick RJ, Lumbard K, Pau A, Poole A, Kibiy A, Kumar P, Sereti I. A Phase I, Randomized, Controlled Clinical Study of CC-11050 in People Living With HIV With Suppressed Plasma Viremia on Antiretroviral Therapy (APHRODITE). Open Forum Infect Dis. 2019 Jun 3;6(6):ofz246. doi: 10.1093/ofid/ofz246. PMID: 31211164; PMCID: PMC6559277.
2: Subbian S, Tsenova L, Holloway J, Peixoto B, O’Brien P, Dartois V, Khetani V, Zeldis JB, Kaplan G. Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model. EBioMedicine. 2016 Jan 14;4:104-14. doi: 10.1016/j.ebiom.2016.01.015. PMID: 26981575; PMCID: PMC4776074.
3: Subbian S, Koo MS, Tsenova L, Khetani V, Zeldis JB, Fallows D, Kaplan G. Pharmacologic Inhibition of Host Phosphodiesterase-4 Improves Isoniazid-Mediated Clearance of Mycobacterium tuberculosis. Front Immunol. 2016 Jun 17;7:238. doi: 10.3389/fimmu.2016.00238. PMID: 27379099; PMCID: PMC4911353.

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