CC-122

• CAT Number: I000128
• CAS Number: 1015474-32-4
• Molecular Formula: C₁₄H₁₄N₄O₃
• Molecular Weight: 286.29
• Purity: ≥95%
• Target: pleiotropic pathway modulator
• Solubility: DMSO ≥ 33 mg/mL
• Storage: -20°C
• IUPAC Name: 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
• InChI: InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20)
• InChIKey: RSNPAKAFCAAMBH-UHFFFAOYSA-N
• SMILES: CC1=NC2=CC=CC(=C2C(=O)N1C3CCC(=O)NC3=O)N

CC-122（Cat No.:I000128）is a potent immunomodulatory compound with anticancer properties, belonging to the class of cereblon (CRBN) modulators. It functions by binding to CRBN, a key component of the E3 ubiquitin ligase complex, leading to targeted degradation of transcription factors essential for cancer cell survival. This action promotes apoptosis and inhibits tumor growth, making CC-122 valuable in treating hematologic malignancies and certain solid tumors. Additionally, it exhibits immune-enhancing effects, such as stimulating T-cells and natural killer cells, positioning it as a promising candidate in cancer immunotherapy research and development.

Reference

[1]. Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89.