CC-401

• CAT Number: I003443
• CAS Number: 395104-30-0
• Molecular Formula: C22H24N6O
• Molecular Weight: 388.50
• Purity: ≥95%
• Synonyms: 3-[3-(2-piperidin-1-ylethoxy)phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
• Target: JNK
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• InChI: InChI=1S/C22H24N6O/c1-2-9-28(10-3-1)11-12-29-18-6-4-5-16(13-18)21-19-14-17(22-23-15-24-27-22)7-8-20(19)25-26-21/h4-8,13-15H,1-3,9-12H2,(H,25,26)(H,23,24,27)
• InChIKey: XDJCLCLBSGGNKS-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5

CC-401 (Cat No.:I003443) is a selective inhibitor of Janus kinase 2 (JAK2), a tyrosine kinase involved in intracellular signaling pathways. It inhibits JAK2 by binding to its ATP-binding site, preventing the phosphorylation of downstream targets and the activation of cytokine signaling pathways. CC-401 has shown potential in the treatment of myeloproliferative neoplasms, a group of disorders characterized by abnormal production of blood cells. By inhibiting JAK2, CC-401 can help reduce the overproduction of blood cells and alleviate disease symptoms. It is still under investigation for its therapeutic applications and potential benefits in various hematological malignancies.