For research use only. Not for therapeutic Use.
CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.
CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity[1].
| Catalog Number | I046281 |
| CAS Number | 1621999-82-3 |
| Synonyms | N-[2-[[2-[(2-methoxy-5-methylpyridin-4-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]-5-methylphenyl]prop-2-enamide |
| Molecular Formula | C22H21F3N6O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H21F3N6O2/c1-5-18(32)28-17-8-12(2)6-7-15(17)29-20-14(22(23,24)25)11-27-21(31-20)30-16-9-19(33-4)26-10-13(16)3/h5-11H,1H2,2-4H3,(H,28,32)(H2,26,27,29,30,31) |
| InChIKey | ILUKRINUNLAVMH-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)NC2=NC(=NC=C2C(F)(F)F)NC3=CC(=NC=C3C)OC)NC(=O)C=C |
| Reference | [1]. Monica M. Mita, et al. A phase Ia study of CC-90003, a selective extracellular signal-regulated kinase (ERK) inhibitor, in patients with relapsed or refractory BRAF or RAS-mutant tumors. Journal of Clinical Oncology 35, no. 15_suppl (May 20 2017) 2577-257 |
