CC-92480

• CAT Number: I017794
• CAS Number: 2259648-80-9
• Molecular Formula: C₃₂H₃₀FN₅O₄
• Molecular Weight: 567.61
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile
• InChI: InChI=1S/C32H30FN5O4/c33-26-16-23(17-34)8-9-27(26)37-14-12-36(13-15-37)18-21-4-6-22(7-5-21)20-42-29-3-1-2-24-25(29)19-38(32(24)41)28-10-11-30(39)35-31(28)40/h1-9,16,28H,10-15,18-20H2,(H,35,39,40)/t28-/m0/s1
• InChIKey: YTINZZFBHWSAGL-NDEPHWFRSA-N
• SMILES: C1CC(=O)NC(=O)[C@H]1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCN(CC5)C6=C(C=C(C=C6)C#N)F

CC-92480（Cat No.:I017794）is a potent, selective cereblon (CRBN) modulator, designed to degrade specific proteins involved in cancer cell survival, particularly in multiple myeloma. As a cereblon E3 ligase modulator (CELMoD), CC-92480 induces the targeted degradation of transcription factors Ikaros and Aiolos, which are crucial for tumor cell proliferation and immune evasion. This selective degradation mechanism has shown promise in preclinical and clinical studies, demonstrating strong anti-tumor efficacy and potential in overcoming drug resistance. CC-92480 is actively explored as an innovative therapeutic in cancer treatment strategies, especially for relapsed or refractory multiple myeloma.

Reference

[1]. Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31.