CC214-2

• CAT Number: I024225
• CAS Number: 1228012-18-7
• Molecular Formula: C20H25N5O3
• Molecular Weight: 383.45
• Purity: 98%
• Synonyms: CC2142; CC214-2; CC214 2
• Target: Autophagy
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(oxan-4-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one
• InChI: InChI=1S/C20H25N5O3/c1-20(2,27)16-4-3-14(9-21-16)15-10-22-18-19(23-15)25(12-17(26)24-18)11-13-5-7-28-8-6-13/h3-4,9-10,13,27H,5-8,11-12H2,1-2H3,(H,22,24,26)
• InChIKey: UWUPKVZQISLSSA-UHFFFAOYSA-N
• SMILES: CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(CC(=O)N3)CC4CCOCC4)O

CC214-2（Cat No.:I024225）is a small molecule compound that has been studied for its potential as a selective antagonist of certain receptors, particularly those involved in neurotransmission and inflammatory processes. It is most notable for its activity against the histamine H3 receptor, a G-protein-coupled receptor involved in regulating neurotransmitter release and brain function. By blocking this receptor, CC214-2 has potential therapeutic applications in conditions like sleep disorders, cognitive dysfunction, and certain psychiatric conditions. While preclinical studies show promise, further research and clinical trials are required to determine its safety, efficacy, and potential therapeutic uses.

Reference

1: Herrero-Sánchez MC, Rodríguez-Serrano C, Almeida J, San-Segundo L, Inogés S, Santos-Briz Á, García-Briñón J, SanMiguel JF, Del Cañizo C, Blanco B. Effect of mTORC1/mTORC2 inhibition on T cell function: potential role in graft-versus-host disease control. Br J Haematol. 2016 Jun;173(5):754-68. doi: 10.1111/bjh.13984. Epub 2016 Feb 23. PubMed PMID: 26914848.
2: Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15;19(20):5722-32. doi: 10.1158/1078-0432.CCR-13-0527. Epub 2013 Sep 12. PubMed PMID: 24030701; PubMed Central PMCID: PMC3815450.
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