CCG-203586

• CAT Number: I024241
• CAS Number: 1430611-23-6
• Molecular Formula: C26H32N2O4
• Molecular Weight: 436.55
• Purity: 98%
• Synonyms: CCG-203586; CCG203586; CCG 203586; EtDO-PIP2; EtDOPIP2; EtDO PIP2
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)acetamide
• InChI: InChI=1S/C26H32N2O4/c29-25(15-18-13-19-5-1-2-6-20(19)14-18)27-22(17-28-9-3-4-10-28)26(30)21-7-8-23-24(16-21)32-12-11-31-23/h1-2,5-8,16,18,22,26,30H,3-4,9-15,17H2,(H,27,29)/t22-,26-/m1/s1
• InChIKey: WXPGOGVMRCVPDZ-ATIYNZHBSA-N
• SMILES: O=C(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)CC4CC5=C(C=CC=C5)C4

CCG-203586 (Cat No.: I024241) is a small-molecule inhibitor that targets the Rho/MRTF/SRF transcriptional pathway, which plays a key role in fibrosis, cancer progression, and inflammatory responses. By inhibiting myocardin-related transcription factor (MRTF) activity, CCG-203586 suppresses the expression of genes involved in myofibroblast activation and extracellular matrix production. It is primarily used in preclinical studies to explore therapeutic strategies for fibrotic diseases such as systemic sclerosis and pulmonary fibrosis. CCG-203586 serves as a valuable tool for investigating MRTF-mediated signaling and antifibrotic drug development.

Reference

1: Arthur JR, Wilson MW, Larsen SD, Rockwell HE, Shayman JA, Seyfried TN. Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice. Neurochem Res. 2013 Apr;38(4):866-75. doi: 10.1007/s11064-013-0992-5. Epub 2013 Feb 16. PMID: 23417430; PMCID: PMC6554746.
2: Larsen SD, Wilson MW, Abe A, Shu L, George CH, Kirchhoff P, Showalter HD, Xiang J, Keep RF, Shayman JA. Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain. J Lipid Res. 2012 Feb;53(2):282-91. doi: 10.1194/jlr.M021261. Epub 2011 Nov 4. PMID: 22058426; PMCID: PMC3269155.