For research use only. Not for therapeutic Use.
CCG-203586 is a novel potent glucosylceramide synthase (GCS) inhibitor.
| Catalog Number | I024241 |
| CAS Number | 1430611-23-6 |
| Synonyms | CCG-203586; CCG203586; CCG 203586; EtDO-PIP2; EtDOPIP2; EtDO PIP2; |
| Molecular Formula | C26H32N2O4 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-(2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)acetamide |
| InChI | InChI=1S/C26H32N2O4/c29-25(15-18-13-19-5-1-2-6-20(19)14-18)27-22(17-28-9-3-4-10-28)26(30)21-7-8-23-24(16-21)32-12-11-31-23/h1-2,5-8,16,18,22,26,30H,3-4,9-15,17H2,(H,27,29)/t22-,26-/m1/s1 |
| InChIKey | WXPGOGVMRCVPDZ-ATIYNZHBSA-N |
| SMILES | O=C(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)CC4CC5=C(C=CC=C5)C4 |
| Reference | 1: Arthur JR, Wilson MW, Larsen SD, Rockwell HE, Shayman JA, Seyfried TN. Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice. Neurochem Res. 2013 Apr;38(4):866-75. doi: 10.1007/s11064-013-0992-5. Epub 2013 Feb 16. PMID: 23417430; PMCID: PMC6554746. |
