CCPG

• CAT Number: I024249
• CAS Number: 22255-17-0
• Molecular Formula: C6H9NO4
• Molecular Weight: 159.14
• Purity: 98%
• Synonyms: (alpha-Carboxycyclopropyl)glycine; CCPG; L-Ccg-I
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(amino(carboxy)methyl)cyclopropane-1-carboxylic acid
• InChI: InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)
• InChIKey: GZOVEPYOCJWRFC-UHFFFAOYSA-N
• SMILES: O=C(O)C(N)C1C(C(O)=O)C1

CCPG (Cyclin-dependent kinase (CDK) regulatory protein) (Cat No.: I024249) is involved in cell cycle regulation and signaling pathways. It modulates the activity of CDKs, which play a crucial role in cell division and proliferation. CCPG has been studied for its potential impact on cancer, as dysregulation of CDK activity is linked to uncontrolled tumor growth. Its function in checkpoint control and interaction with other regulatory proteins make it a target of interest in cancer research and drug discovery, particularly in developing novel CDK inhibitors.

Reference

1: Schlein K. Gastric Versus Small Bowel Feeding in Critically Ill Adults. Nutr Clin Pract. 2016 Aug;31(4):514-22. doi: 10.1177/0884533616629633. Epub 2016 Feb 26. Review. PubMed PMID: 26920643.
2: Zeng J, Mi R, Wang Y, Li Y, Lin L, Yao B, Song L, van Die I, Chapman AB, Cummings RD, Jin P, Ju T. Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation. J Biol Chem. 2015 Jul 31;290(31):19018-33. doi: 10.1074/jbc.M115.654244. Epub 2015 Jun 10. PubMed PMID: 26063800; PubMed Central PMCID: PMC4521027.
3: Samengo IA, Scotti V, Martire M. Co-application of the GABAB receptor agonist, baclofen, and the mGlu receptor agonist, L-CCG-I, facilitates [(3)H]GABA release from rat cortical nerve endings. J Neural Transm (Vienna). 2013 Dec;120(12):1641-9. doi: 10.1007/s00702-013-1057-2. Epub 2013 Jul 3. PubMed PMID: 23821368.
4: Risgaard R, Nielsen SD, Hansen KB, Jensen CM, Nielsen B, Traynelis SF, Clausen RP. Development of 2′-substituted (2S,1’R,2’S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists. J Med Chem. 2013 May 23;56(10):4071-81. doi: 10.1021/jm400346a. Epub 2013 May 9. PubMed PMID: 23614571; PubMed Central PMCID: PMC3689883.
5: Kintscher M, Breustedt J, Miceli S, Schmitz D, Wozny C. Group II metabotropic glutamate receptors depress synaptic transmission onto subicular burst firing neurons. PLoS One. 2012;7(9):e45039. doi: 10.1371/journal.pone.0045039. Epub 2012 Sep 11. PubMed PMID: 22984605; PubMed Central PMCID: PMC3439391.
6: Kumar P, Dubey A, Harbindu A. Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: application to the synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II. Org Biomol Chem. 2012 Sep 14;10(34):6987-94. doi: 10.1039/c2ob25622c. Epub 2012 Jul 26. PubMed PMID: 22832742.
7: Lennon SM, Rivero G, Matharu A, Howson PA, Jane DE, Roberts PJ, Kelly E. Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization. Eur J Pharmacol. 2010 Dec 15;649(1-3):29-37. doi: 10.1016/j.ejphar.2010.08.038. Epub 2010 Sep 15. PubMed PMID: 20826132.
8: Lau CL, Beart PM, O’Shea RD. Transportable and non-transportable inhibitors of L-glutamate uptake produce astrocytic stellation and increase EAAT2 cell surface expression. Neurochem Res. 2010 May;35(5):735-42. doi: 10.1007/s11064-010-0130-6. Epub 2010 Feb 9. PubMed PMID: 20143158.
9: Wostrack M, Dietrich D. Involvement of Group II mGluRs in mossy fiber LTD. Synapse. 2009 Dec;63(12):1060-8. doi: 10.1002/syn.20692. PubMed PMID: 19637276.
10: Levinthal C, Barkdull L, Jacobson P, Storjohann L, Van Wagenen BC, Stormann TM, Hammerland LG. Modulation of group III metabotropic glutamate receptors by hydrogen ions. Pharmacology. 2009;83(2):88-94. doi: 10.1159/000180124. Epub 2008 Dec 9. PubMed PMID: 19065062.
11: Shirasaka T. Development history and concept of an oral anticancer agent S-1 (TS-1): its clinical usefulness and future vistas. Jpn J Clin Oncol. 2009 Jan;39(1):2-15. doi: 10.1093/jjco/hyn127. Epub 2008 Dec 3. PubMed PMID: 19052037; PubMed Central PMCID: PMC2639406.
12: Hansen KB, Bräuner-Osborne H, Egebjerg J. Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements. Comb Chem High Throughput Screen. 2008 May;11(4):304-15. PubMed PMID: 18473740.
13: Li D, Kang Q, Wang DM. Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. Mol Endocrinol. 2007 Oct;21(10):2320-33. Epub 2007 Jun 26. PubMed PMID: 17595322.
14: Smiałowska M, Wierońska JM, Domin H, Zieba B. The effect of intrahippocampal injection of group II and III metobotropic glutamate receptor agonists on anxiety; the role of neuropeptide Y. Neuropsychopharmacology. 2007 Jun;32(6):1242-50. Epub 2006 Nov 29. PubMed PMID: 17133262.
15: Tan Y, Hori N, Carpenter DO. Electrophysiological effects of three groups of glutamate metabotropic receptors in rat piriform cortex. Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):915-24. Epub 2006 Aug 2. PubMed PMID: 16897365.
16: Chaki S, Yoshikawa R, Okuyama S. Group II metabotropic glutamate receptor-mediated regulation of dopamine release from slices of rat nucleus accumbens. Neurosci Lett. 2006 Aug 14;404(1-2):182-6. Epub 2006 Jun 14. PubMed PMID: 16781059.
17: Wierońska JM, Szewczyk B, Pałucha A, Brański P, Zieba B, Smiałowska M. Anxiolytic action of group II and III metabotropic glutamate receptors agonists involves neuropeptide Y in the amygdala. Pharmacol Rep. 2005 Nov-Dec;57(6):734-43. PubMed PMID: 16382191.
18: Nolte CM, Meredith M. mGluR2 activation of medial amygdala input impairs vomeronasal organ-mediated behavior. Physiol Behav. 2005 Oct 15;86(3):314-23. Epub 2005 Oct 10. PubMed PMID: 16216292.
19: Potenza MN, Steinberg MA, Wu R. Characteristics of gambling helpline callers with self-reported gambling and alcohol use problems. J Gambl Stud. 2005 Fall;21(3):233-54. PubMed PMID: 16134007.
20: Llansola M, Erceg S, Felipo V. Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture. Neuroscience. 2005;133(1):185-91. PubMed PMID: 15893642.