CCR1 antagonist 9

For research use only. Not for therapeutic Use.

  • CAT Number: I017409
  • CAS Number: 1220026-26-5
  • Molecular Formula: C20H16FN5O3S
  • Molecular Weight: 425.44
  • Purity: ≥95%
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CCR1 antagonist 9 is a potent and selective CCR1 antagonist with an IC50 of 6.8 nM in calcium flux assay[1].
CCR1 antagonist 9 (Compound 19e) blocks the CCR1 chemotaxis of THP-1 cells with an IC50 of 28 nM. CCR1 antagonist 9 also blocks hERG with an IC50 of 30 μM[1].


Catalog Number I017409
CAS Number 1220026-26-5
Synonyms

1-(4-fluorophenyl)-N-[(2-methylsulfonylpyridin-4-yl)methyl]pyrazolo[3,4-c]pyridine-4-carboxamide

Molecular Formula C20H16FN5O3S
Purity ≥95%
InChI InChI=1S/C20H16FN5O3S/c1-30(28,29)19-8-13(6-7-23-19)9-24-20(27)17-10-22-12-18-16(17)11-25-26(18)15-4-2-14(21)3-5-15/h2-8,10-12H,9H2,1H3,(H,24,27)
InChIKey DCHROQCNJDJPGN-UHFFFAOYSA-N
SMILES CS(=O)(=O)C1=NC=CC(=C1)CNC(=O)C2=CN=CC3=C2C=NN3C4=CC=C(C=C4)F
Reference

[1]. Harcken C, et al. Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett. 2019 Feb 1;29(3):441-448.
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