CCR3 antagonist 1

• CAT Number: I013267
• CAS Number: 879399-82-3
• Molecular Formula: C₁₉H₂₁Cl₂N₃O₄S₂
• Molecular Weight: 490.42
• Purity: ≥95%
• Target: CCR
• Solubility: DMSO
• IUPAC Name: 2-[2-[2-[[(2S)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetic acid
• InChI: InChI=1S/C19H21Cl2N3O4S2/c20-15-2-1-12(5-16(15)21)8-24-3-4-28-14(9-24)7-22-17(25)11-30-19-23-13(10-29-19)6-18(26)27/h1-2,5,10,14H,3-4,6-9,11H2,(H,22,25)(H,26,27)/t14-/m0/s1
• InChIKey: QBXNXHODSIQDRT-AWEZNQCLSA-N
• SMILES: C1CO[C@H](CN1CC2=CC(=C(C=C2)Cl)Cl)CNC(=O)CSC3=NC(=CS3)CC(=O)O

CCR3 Antagonist 1（Cat No.:I013267）is a compound designed to block the activity of the CCR3 receptor, a G-protein coupled receptor involved in immune response, particularly in inflammation and allergic reactions. CCR3 is known to mediate the migration of eosinophils, basophils, and T-helper cells to sites of inflammation. By inhibiting CCR3, Antagonist 1 may help treat conditions like asthma, allergic rhinitis, and other inflammatory disorders. Preclinical studies have shown its potential in reducing inflammatory cell recruitment and symptoms associated with allergic conditions, though its clinical efficacy and safety are still under investigation.