CCR3 antagonist 1

• CAT Number: I013267
• CAS Number: 879399-82-3
• Molecular Formula: C₁₉H₂₁Cl₂N₃O₄S₂
• Molecular Weight: 490.42
• Purity: ≥95%
• Target: CCR
• Solubility: DMSO
• IUPAC Name: 2-[2-[2-[[(2S)-4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetic acid
• InChI: InChI=1S/C19H21Cl2N3O4S2/c20-15-2-1-12(5-16(15)21)8-24-3-4-28-14(9-24)7-22-17(25)11-30-19-23-13(10-29-19)6-18(26)27/h1-2,5,10,14H,3-4,6-9,11H2,(H,22,25)(H,26,27)/t14-/m0/s1
• InChIKey: QBXNXHODSIQDRT-AWEZNQCLSA-N
• SMILES: C1COC(CN1CC2=CC(=C(C=C2)Cl)Cl)CNC(=O)CSC3=NC(=CS3)CC(=O)O

CCR3 antagonist 1 is a potent antagonist of CCR3, with an IC50 of 1.8 nM, and used for the research of immunologic and inflammatory diseases.

Reference

[1]. MORPHOLINE COMPOUND. WO 2006028284 A1