For research use only, not for therapeutic use.
CCT-129202（Cat No.:I005607）is a potent, selective inhibitor of ribosomal S6 kinase (RSK) and Aurora kinase, both involved in cell cycle regulation and proliferation. By inhibiting these kinases, CCT-129202 disrupts key signaling pathways that promote tumor growth and survival. It has shown efficacy in preclinical studies by inducing apoptosis and cell cycle arrest in cancer cells, particularly those with dysregulated kinase activity. CCT-129202 is being studied for its potential to treat various cancers, including breast and colorectal cancer, making it a valuable tool in cancer research and therapeutic development.
| Catalog Number | I005607 |
| CAS Number | 942947-93-5 |
| Synonyms | CCT-129202; |
| Molecular Formula | C₂₃H₂₅ClN₈OS |
| Purity | ≥95% |
| Target | Aurora Kinase |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20℃ powder |
| IC50 | IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μmol/L for Aurora A, Aurora B, and Aurora C |
| IUPAC Name | 2-[4-[6-chloro-2-[4-(dimethylamino)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide |
| InChI | InChI=1S/C23H25ClN8OS/c1-30(2)16-5-3-15(4-6-16)21-28-19-20(17(24)13-26-22(19)29-21)32-10-8-31(9-11-32)14-18(33)27-23-25-7-12-34-23/h3-7,12-13H,8-11,14H2,1-2H3,(H,25,27,33)(H,26,28,29) |
| InChIKey | QYKHWEFPFAGNEV-UHFFFAOYSA-N |
| SMILES | CN(C)C1=CC=C(C=C1)C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC(=O)NC5=NC=CS5)Cl |
| Reference | </br>1:Protein kinase C modulates Aurora-kinase inhibition induced by CCT129202 in HMC-1⁵⁶⁰,⁸¹⁶ cell line. Tobío A, Alfonso A, Fernández-Araujo A, Alonso E, Botana LM.Antiinflamm Antiallergy Agents Med Chem. 2013;12(3):265-76. PMID: 23701310 </br>2:Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202. Cheng C, Liu ZG, Zhang H, Xie JD, Chen XG, Zhao XQ, Wang F, Liang YJ, Chen LK, Singh S, Chen JJ, Talele TT, Chen ZS, Zhong FT, Fu LW.Mol Pharm. 2012 Jul 2;9(7):1971-82. doi: 10.1021/mp2006714. Epub 2012 Jun 13. PMID: 22632055 </br>3:Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Chan F, Sun C, Perumal M, Nguyen QD, Bavetsias V, McDonald E, Martins V, Wilsher NE, Raynaud FI, Valenti M, Eccles S, Te Poele R, Workman P, Aboagye EO, Linardopoulos S.Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57. PMID: 18089709 Free Article |
