CCT007093

• CAT Number: I002302
• CAS Number: 176957-55-4
• Molecular Formula: C15H12OS2
• Molecular Weight: 272.40
• Purity: ≥95%
• Synonyms: (2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one
• Target: Apoptosis
• Solubility: DMSO: ≥ 2.7 mg/mL, DMSO: ＜ 5.1 mg/mL
• Storage: Store at -20℃
• IUPAC Name: (2E,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one
• InChI: InChI=1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+
• InChIKey: KPFZCKDPBMGECB-WGDLNXRISA-N
• SMILES: C1/C(=C\C2=CC=CS2)/C(=O)/C(=C/C3=CC=CS3)/C1

CCT007093（Cat No.:I002302）is a selective inhibitor of the protein phosphatase PPM1D (also known as WIP1), a regulator of the p53 tumor suppressor pathway. By inhibiting PPM1D, CCT007093 enhances p53 activity, leading to cell cycle arrest and promoting apoptosis in cancer cells with wild-type p53. This compound has gained attention in oncology research for its potential to sensitize cancer cells to chemotherapy and radiation, making it a valuable tool for exploring tumor suppression mechanisms. Its specificity and efficacy support its use in preclinical cancer studies and therapeutic strategy development.

Reference

[1]. Rayter S, et al. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27(8):1036-44.
[2]. Buss MC, et al. HDM2 promotes WIP1-mediated medulloblastoma growth. Neuro Oncol. 2012 Apr;14(4):440-58.
[3]. Lee JS, et al. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014 Feb;73(2):125-34.