For research use only. Not for therapeutic Use.
CCT128930 (Cat No.:I005317) is a potent and selective ATP-competitive inhibitor of Akt2, with an IC50 of 6 nM. It exhibits more than 28-fold selectivity for Akt2 compared to the closely related PKA kinase. By inhibiting Akt activity in vitro and in vivo, CCT128930 elicits significant antitumor responses. It demonstrates strong antiproliferative activity and effectively inhibits the phosphorylation of various Akt substrates in multiple tumor cell lines, indicating its ability to block the Akt pathway. In PTEN-null U87MG human glioblastoma cells, CCT128930 induces G1 cell cycle arrest, consistent with its inhibition of the Akt pathway and its potential as a therapeutic agent against cancer.
| Catalog Number | I005317 |
| CAS Number | 885499-61-6 |
| Synonyms | CCT128930; CCT 128930; CCT-128930;4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine |
| Molecular Formula | C18H20ClN5 |
| Purity | ≥95% |
| Target | Akt |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 0.6 nM |
| IUPAC Name | 4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine |
| InChI | InChI=1S/C18H20ClN5/c19-14-3-1-13(2-4-14)11-18(20)6-9-24(10-7-18)17-15-5-8-21-16(15)22-12-23-17/h1-5,8,12H,6-7,9-11,20H2,(H,21,22,23) |
| InChIKey | RZIDZIGAXXNODG-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
| Reference | <br /> |
