CCT241533 hydrochloride

• CAT Number: I001665
• CAS Number: 1431697-96-9
• Molecular Formula: C23H28ClFN4O4
• Molecular Weight: 478.94
• Purity: ≥95%
• Synonyms: (6Z)-4-fluoro-6-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxy-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one;hydrochloride
• Target: Checkpoint Kinase (Chk)
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 3 nM
• IUPAC Name: 4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol;hydrochloride
• InChI: InChI=1S/C23H27FN4O4.ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29;/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28);1H/t15-,17-;/m1./s1
• InChIKey: LAKJUTZIXHTMPC-SSPJITILSA-N
• SMILES: CC(C)([C@@H]1CNC[C@H]1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O.Cl

CCT241533 Hydrochloride（Cat No.:I001665）is a potent and selective inhibitor of checkpoint kinase 1 (CHK1), a key regulator in DNA damage response. By inhibiting CHK1, CCT241533 hydrochloride enhances the cytotoxic effects of DNA-damaging agents, making it valuable for cancer research. This compound plays a crucial role in understanding the mechanisms of cell cycle regulation and tumor suppression, providing a potential pathway for new therapeutic strategies. Its high specificity and efficacy make it ideal for studies in oncology and the development of novel cancer treatments.

Reference

[1]. Anderson VE, Walton MI, Eve PD, Boxall KJ, Antoni L, Caldwell JJ, Aherne W, Pearl LH, Oliver AW, Collins I, Garrett MD. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72.
[2]. Caldwell JJ, Welsh EJ, Matijssen C, Anderson VE, Antoni L, Boxall K, Urban F, Hayes A, Raynaud FI, Rigoreau LJ, Raynham T, Aherne GW, Pearl LH, Oliver AW, Garrett MD, Collins I. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90.