For research use only. Not for therapeutic Use.
CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro. CCT374705 effectively inhibits tumor growth in a lymphoma xenograft mouse model[1].
| Catalog Number | I040931 |
| CAS Number | 2640647-90-9 |
| Synonyms | (2S)-10-[(3-chloro-2-fluoropyridin-4-yl)amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one |
| Molecular Formula | C21H18ClF3N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H18ClF3N4O2/c1-29-14-5-4-11(27-13-6-7-26-19(23)15(13)22)8-12(14)16-17(20(29)30)31-9-21(24,25)18(28-16)10-2-3-10/h4-8,10,18,28H,2-3,9H2,1H3,(H,26,27)/t18-/m0/s1 |
| InChIKey | MCRHRRIGPAVFNY-SFHVURJKSA-N |
| SMILES | CN1C2=C(C=C(C=C2)NC3=C(C(=NC=C3)F)Cl)C4=C(C1=O)OCC(C(N4)C5CC5)(F)F |
| Reference | [1]. Harnden AC, et al. Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones. J Med Chem. 2023 Apr 27;66(8):5892-5906. |
