For research use only. Not for therapeutic Use.
CCX354 is an antagonist of CCR1, with anti-inflammatory activity.
CCX354 shows potent activities in the chemotaxis assay, with IC50 < 100 nM[1].
In vivo, CCX354 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties[1].
| Catalog Number | I024263 |
| CAS Number | 1010073-75-2 |
| Synonyms | 1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]ethanone |
| Molecular Formula | C22H22ClN7O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H22ClN7O2/c1-32-18-13-15(4-5-17(18)23)28-9-11-29(12-10-28)19(31)14-30-22-16(3-2-6-26-22)20(27-30)21-24-7-8-25-21/h2-8,13H,9-12,14H2,1H3,(H,24,25) |
| InChIKey | ZIMLRKWQDLVPEK-UHFFFAOYSA-N |
| SMILES | COC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C4=C(C=CC=N4)C(=N3)C5=NC=CN5)Cl |
| Reference | [1]. Compounds for the treatment of osteoporosis and cancers. US 20100113472 A1 |
