For research use only. Not for therapeutic Use.
CD12681 is a potent RORγ inverse agonist with an IC50 value of 19 nM. CD12681 showed in vivo activity in an IL-23 induced skin inflammation model in mouse. Preclinical candidate for the topical treatment of psoriasis.
KEYWORDS: CD12681 | supplier | RORγ agonist | CD 12681 | CD-12681 | CAS [1952239-59-6] | Retinoic Acid | ROR | Inverse agonist | Receptors | Psoriasis
| Catalog Number | I024269 |
| CAS Number | 1952239-59-6 |
| Molecular Formula | C25H33N3O4S |
| Purity | ≥95% |
| IUPAC Name | N-(2,4-dimethylphenyl)-N-(2-methylpropyl)-1-(oxan-4-ylmethyl)-2-oxo-3H-benzimidazole-5-sulfonamide |
| InChI | InChI=1S/C25H33N3O4S/c1-17(2)15-28(23-7-5-18(3)13-19(23)4)33(30,31)21-6-8-24-22(14-21)26-25(29)27(24)16-20-9-11-32-12-10-20/h5-8,13-14,17,20H,9-12,15-16H2,1-4H3,(H,26,29) |
| SMILES | CC1=CC(=C(C=C1)N(CC(C)C)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)N3)CC4CCOCC4)C |
| Reference | G Ouvry et al. Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis. ChemMedChem. 2018 Feb 20;13(4):321-337 |
