For research use only. Not for therapeutic Use.
CD24/Siglec-10 blocking peptide, CSBP can not only block the interaction of CD24/Siglec-10 but also PD-1/PD-L1. CD24/Siglec-10 blocking peptide, CSBP can induce the phagocytosis of tumor cell[1].
| Catalog Number | I040206 |
| Synonyms | (2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]pentanedioic acid |
| Molecular Formula | C47H68N8O15 |
| Purity | ≥95% |
| InChI | InChI=1S/C47H68N8O15/c1-24(2)18-30(48)40(62)50-35(22-38(60)61)44(66)55-39(26(5)6)46(68)53-34(20-27-10-8-7-9-11-27)42(64)51-32(19-25(3)4)41(63)52-33(21-28-12-14-29(57)15-13-28)43(65)54-36(23-56)45(67)49-31(47(69)70)16-17-37(58)59/h7-15,24-26,30-36,39,56-57H,16-23,48H2,1-6H3,(H,49,67)(H,50,62)(H,51,64)(H,52,63)(H,53,68)(H,54,65)(H,55,66)(H,58,59)(H,60,61)(H,69,70)/t30-,31-,32-,33-,34-,35-,36-,39-/m1/s1 |
| InChIKey | OYUKIHOFWJFQQK-HRCXZZMQSA-N |
| SMILES | CC(C)CC(C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)O)N |
| Reference | [1]. Wenhui Shen, et al. Discovery of a novel dual-targeting D-peptide to block CD24/Siglec-10 and PD-1/PD-L1 interaction and synergize with radiotherapy for cancer immunotherapy. J Immunother Cancer. 2023 Jun;11(6):e007068. |
