For research use only. Not for therapeutic Use.
CD33 Splicing Modulator 1（Cat No.:I044050）is a small-molecule compound that alters the splicing pattern of the CD33 gene, promoting the exclusion of exon 2 and thereby reducing expression of the full-length CD33 protein on the cell surface. CD33 is a myeloid cell surface marker implicated in acute myeloid leukemia (AML) and targeted by immunotherapies. By modulating splicing, this compound can impact CD33-mediated signaling and immune recognition, making it a valuable tool in AML research. CD33 Splicing Modulator 1 supports exploration of alternative splicing as a therapeutic strategy in hematologic malignancies.
| CAS Number | 2762547-05-5 |
| Synonyms | 3-fluoro-4-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-methylpyridin-2-yl)-N-[(3R)-piperidin-3-yl]benzamide |
| Molecular Formula | C25H25FN6O |
| Purity | ≥95% |
| IUPAC Name | 3-fluoro-4-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-methylpyridin-2-yl)-N-[(3R)-piperidin-3-yl]benzamide |
| InChI | InChI=1S/C25H25FN6O/c1-16-12-29-24-21(14-30-31(24)15-16)20-8-7-18(11-22(20)26)25(33)32(19-6-4-9-27-13-19)23-17(2)5-3-10-28-23/h3,5,7-8,10-12,14-15,19,27H,4,6,9,13H2,1-2H3/t19-/m1/s1 |
| InChIKey | YTRBUPKEYPDQGD-LJQANCHMSA-N |
| SMILES | CC1=C(N=CC=C1)N([C@@H]2CCCNC2)C(=O)C3=CC(=C(C=C3)C4=C5N=CC(=CN5N=C4)C)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
