For research use only. Not for therapeutic Use.
CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. CD33 splicing modulator 1 increases exon 2 skipping in cellular mRNA pools. CD33 splicing modulator 1 has the potential for the research of neurodegenerative disease including Alzheimer’s disease[1].
| Catalog Number | I044050 |
| CAS Number | 2762547-05-5 |
| Synonyms | 3-fluoro-4-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-methylpyridin-2-yl)-N-[(3R)-piperidin-3-yl]benzamide |
| Molecular Formula | C25H25FN6O |
| Purity | ≥95% |
| InChI | InChI=1S/C25H25FN6O/c1-16-12-29-24-21(14-30-31(24)15-16)20-8-7-18(11-22(20)26)25(33)32(19-6-4-9-27-13-19)23-17(2)5-3-10-28-23/h3,5,7-8,10-12,14-15,19,27H,4,6,9,13H2,1-2H3/t19-/m1/s1 |
| InChIKey | YTRBUPKEYPDQGD-LJQANCHMSA-N |
| SMILES | CC1=C(N=CC=C1)N(C2CCCNC2)C(=O)C3=CC(=C(C=C3)C4=C5N=CC(=CN5N=C4)C)F |
| Reference | [1]. Chappie TA, et al. Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators. ACS Med Chem Lett. 2022;13(1):55-62. |
