CD73-IN-5

• CAT Number: I045148
• CAS Number: 2412019-99-7
• Molecular Formula: C24H15FN8
• Molecular Weight: 434.43
• Purity: ≥95%
• Synonyms: 4-[[5-[7-fluoro-3-(1H-indazol-6-yl)benzotriazol-5-yl]pyrazol-1-yl]methyl]benzonitrile
• InChI: InChI=1S/C24H15FN8/c25-20-9-18(22-7-8-28-32(22)14-16-3-1-15(12-26)2-4-16)10-23-24(20)30-31-33(23)19-6-5-17-13-27-29-21(17)11-19/h1-11,13H,14H2,(H,27,29)
• InChIKey: SWFRQIKTNNVFAU-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CN2C(=CC=N2)C3=CC4=C(C(=C3)F)N=NN4C5=CC6=C(C=C5)C=NN6)C#N

CD73-IN-5 is a potent and selective non-nucleotide small molecule inhibitor of CD73 (IC50 = 19 nM).

Reference

[1]. Beatty JW, et al. Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73. J Med Chem. 2020 Apr 23;63(8):3935-3955.
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