CD80-IN-3

• CAT Number: I015606
• CAS Number: 486449-65-4
• Molecular Formula: C₁₇H₁₀FN₃O₃
• Molecular Weight: 323.28
• Purity: ≥95%
• Target: CD28
• IUPAC Name: 4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]quinolin-2-yl)benzoic acid
• InChI: InChI=1S/C17H10FN3O3/c18-13-3-1-2-11-14-12(8-19-15(11)13)16(22)21(20-14)10-6-4-9(5-7-10)17(23)24/h1-8,20H,(H,23,24)
• InChIKey: NLGJRBLPUVEYKC-UHFFFAOYSA-N
• SMILES: C1=CC2=C3C(=CN=C2C(=C1)F)C(=O)N(N3)C4=CC=C(C=C4)C(=O)O

CD80-IN-3 (Cat No.: I015606) is a potent inhibitor of CD80, a cell surface protein involved in immune responses. CD80 plays a critical role in T cell activation by interacting with its receptor, CD28. By inhibiting the interaction between CD80 and CD28, CD80-IN-3 disrupts the co-stimulatory signaling required for T cell activation and immune response. This inhibition of CD80/CD28 interaction has potential therapeutic applications in modulating immune responses, such as in autoimmune diseases or transplant rejection.