For research use only. Not for therapeutic Use.
CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase[1].
| Catalog Number | I018699 |
| CAS Number | 2374831-10-2 |
| Synonyms | ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate |
| Molecular Formula | C20H19NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H19NO3/c1-3-24-20(22)15-8-6-9-16(11-15)21-19-13-17(23-2)12-14-7-4-5-10-18(14)19/h4-13,21H,3H2,1-2H3 |
| InChIKey | UCMCQFKDMRVNDS-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=CC(=CC=C1)NC2=CC(=CC3=CC=CC=C32)OC |
| Reference | [1]. Cerchia C, et al. Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines. J Med Che |
