Cdc7-IN-1

• CAT Number: I018768
• CAS Number: 1402055-25-7
• Molecular Formula: C₂₁H₁₆ClN₃O₄
• Molecular Weight: 409.82
• Purity: ≥95%
• IUPAC Name: ethyl 2-(2-chloroanilino)-4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]furan-3-carboxylate
• InChI: InChI=1S/C21H16ClN3O4/c1-2-28-21(27)17-18(26)16(10-12-11-24-19-13(12)6-5-9-23-19)29-20(17)25-15-8-4-3-7-14(15)22/h3-11,25-26H,2H2,1H3/b12-10+
• InChIKey: MNEODYFHQBZJNQ-ZRDIBKRKSA-N
• SMILES: CCOC(=O)C1=C(OC(=C1O)/C=C/2\C=NC3=C2C=CC=N3)NC4=CC=CC=C4Cl

Cdc7-IN-1（Cat No.:I018768）is a selective inhibitor of cyclin-dependent kinase 7 (Cdc7), an important enzyme involved in the regulation of DNA replication and cell division. By targeting Cdc7, this compound disrupts the cell cycle, particularly during the S phase, leading to reduced proliferation of cancer cells. Preclinical studies have shown that Cdc7-IN-1 can effectively inhibit tumor growth and enhance the efficacy of existing chemotherapeutic agents. Ongoing research is focused on elucidating its mechanism of action and evaluating its potential applications in various malignancies, aiming to develop novel cancer therapies.

Reference

[1]. Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418.