For research use only. Not for therapeutic Use.
CDD-1653 is a first-in-class, highly potent, and selective BMPR2 kinase inhibitor with an IC50 value of 2.8 nM.
KEYWORDS: CDD-1653 | Supplier | BMPR2 inhibitor | CDD 1653 | CDD1653 | CAS [3034216-44-6] | TGF-β | BMP-ALK | Inhibitor | Receptors
| Catalog Number | I047705 |
| CAS Number | 3034216-44-6 |
| Molecular Formula | C21H22N6O4S |
| Purity | ≥95% |
| IUPAC Name | 3-[[5-methoxy-4-(3-oxo-4-phenylpiperazin-1-yl)pyrimidin-2-yl]amino]benzenesulfonamide |
| InChI | InChI=1S/C21H22N6O4S/c1-31-18-13-23-21(24-15-6-5-9-17(12-15)32(22,29)30)25-20(18)26-10-11-27(19(28)14-26)16-7-3-2-4-8-16/h2-9,12-13H,10-11,14H2,1H3,(H2,22,29,30)(H,23,24,25) |
| SMILES | COC1=CN=C(N=C1N2CCN(C(=O)C2)C3=CC=CC=C3)NC4=CC(=CC=C4)S(=O)(=O)N |
| Reference | RK Modukuri et al. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Feb 9;66(3):2143-2160. |
