For research use only. Not for therapeutic Use.
CDDO-3P-Im（Cat No.:I016177） is an analog of CDDO imidazoline that exhibits chemopreventive properties. It has been shown to reduce the size and severity of lung tumors in a mouse model of lung cancer. CDDO-3P-Im is also an orally active inhibitor of necroptosis, a form of programmed cell death, and can be used in the study of ischemia/reperfusion (I/R). This compound has potential therapeutic applications in cancer prevention and treatment, as well as in the development of novel therapies for conditions related to I/R.
| Catalog Number | I016177 |
| CAS Number | 1883650-95-0 |
| Molecular Formula | C₃₉H₄₆N₄O₃ |
| Purity | ≥95% |
| Target | Apoptosis |
| Storage | Store at -20°C |
| IUPAC Name | (4aR,6aR,6aS,6bR,8aS,12aS,14bS)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-8a-(4-pyridin-3-ylimidazole-1-carbonyl)-4a,5,6,6a,7,8,9,10,12,12a-decahydropicene-2-carbonitrile |
| InChI | InChI=1S/C39H46N4O3/c1-34(2)12-14-39(33(46)43-22-27(42-23-43)24-9-8-16-41-21-24)15-13-38(7)31(26(39)19-34)28(44)17-30-36(5)18-25(20-40)32(45)35(3,4)29(36)10-11-37(30,38)6/h8-9,16-18,21-23,26,29,31H,10-15,19H2,1-7H3/t26-,29-,31-,36-,37+,38+,39-/m0/s1 |
| InChIKey | GXKRPLQWYWDFQN-CXUPGZSSSA-N |
| SMILES | CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)N6C=C(N=C6)C7=CN=CC=C7)C |
| Reference | [1]. Cao M , et al. Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention. Pharmacol Res. 2015 Oct;100:135-47.<br>[2]. Yuanyuan Wang, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. Eur J Med Chem. 2020 Nov 21;113030. |
