For research use only. Not for therapeutic Use.
Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor, with an IC50 of 2.1 μM for CDK1/cyclin B[1].
Cdk1/2 Inhibitor III has weak CDK1 and cellular antiproliferative potencies[1].
| Catalog Number | R032979 |
| CAS Number | 443798-55-8 |
| Synonyms | 3-amino-N-(2,6-difluorophenyl)-5-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide |
| Molecular Formula | C15H13F2N7O2S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-14(22-13(18)23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23) |
| InChIKey | UPNMPXFYMWBVBA-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)F)NC(=S)N2C(=NC(=N2)N)NC3=CC=C(C=C3)S(=O)(=O)N)F |
| Reference | [1]. Lin R, et al. Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11. |
