CDK1-IN-2

• CAT Number: R066974
• CAS Number: 220749-41-7
• Molecular Formula: C17H11ClN2O
• Molecular Weight: 294.74
• Purity: ≥95%
• Synonyms: (3E)-3-[(2-chloro-1H-indol-3-yl)methylidene]-1H-indol-2-one
• InChI: InChI=1S/C17H11ClN2O/c18-16-12(10-5-1-3-7-14(10)19-16)9-13-11-6-2-4-8-15(11)20-17(13)21/h1-9,19H,(H,20,21)/b13-9+
• InChIKey: QJKBRWSJWQVKLY-UKTHLTGXSA-N
• SMILES: C1=CC=C2C(=C1)C(=CC3=C(NC4=CC=CC=C43)Cl)C(=O)N2

CDK1-IN-2 is a CDK1 inhibitor (IC50: 5.8 μM)[1].
CDK1-IN-2 (“CDK1 inhibitor 1”, 0-19.8 μM, 24 h) arrests HCT-116 cells in G2/M phase[1].

Reference

[1]. Jorda R, et al. How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases? J Med Chem. 2018 Oct 25;61(20):9105-9120.
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