Cdk2/9 Inhibitor

• CAT Number: I024278
• CAS Number: 507487-89-0
• Molecular Formula: C14H12N6O2S
• Molecular Weight: 328.35
• Purity: 98%
• Synonyms: Cdk2/9 Inhibitor
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine
• InChI: InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19)
• InChIKey: DYTKVFHLKPDNRW-UHFFFAOYSA-N
• SMILES: O=[N+](C1=CC(NC2=NC=CC(C3=C(C)N=C(N)S3)=N2)=CC=C1)[O-]

A CDK2/9 inhibitor（Cat No.:I024278）is a small molecule that selectively inhibits cyclin-dependent kinases 2 and 9 (CDK2 and CDK9), which play essential roles in cell cycle regulation and transcription. CDK2 is involved in the progression of the cell cycle, particularly the G1 to S phase transition, while CDK9 regulates transcription elongation by RNA polymerase II. By inhibiting both kinases, these inhibitors can halt cancer cell proliferation and promote apoptosis. CDK2/9 inhibitors are being explored for their therapeutic potential in oncology, particularly for treating cancers driven by dysregulated cell cycle and transcription processes.