For research use only. Not for therapeutic Use.
CDK4/6-IN-11（Cat No.:I043863）is a potent, selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), enzymes crucial for regulating the cell cycle, particularly the transition from the G1 to S phase. By inhibiting CDK4/6, this compound halts cell cycle progression, preventing uncontrolled cell proliferation, a hallmark of many cancers. CDK4/6-IN-11 shows promise in treating cancers such as breast cancer, melanoma, and other CDK4/6-driven tumors. Its targeted mechanism of action offers an effective therapeutic strategy for managing cancer and improving outcomes, particularly in combination with other cancer therapies.
| CAS Number | 2139329-47-6 |
| Synonyms | N-[4-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]butyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide |
| Molecular Formula | C43H49N11O7 |
| Purity | ≥95% |
| IUPAC Name | N-[4-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]butyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide |
| InChI | InChI=1S/C43H49N11O7/c1-25-30-23-47-43(50-38(30)53(27-8-3-4-9-27)41(60)36(25)26(2)55)48-33-14-12-28(22-46-33)52-20-18-51(19-21-52)17-6-5-16-44-35(57)24-45-31-11-7-10-29-37(31)42(61)54(40(29)59)32-13-15-34(56)49-39(32)58/h7,10-12,14,22-23,27,32,45H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,57)(H,49,56,58)(H,46,47,48,50) |
| InChIKey | AWPNCYPNCSCZFL-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)CCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
