CDK4/6/1 Inhibitor

• CAT Number: I019885
• CAS Number: 2099128-41-1
• Molecular Formula: C₂₈H₃₀F₂N₆
• Molecular Weight: 488.57
• Purity: ≥95%
• IUPAC Name: 5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)-N-[5-(1-methylpiperidin-4-yl)pyridin-2-yl]pyrimidin-2-amine
• InChI: InChI=1S/C28H30F2N6/c1-17-28(9-3-4-10-28)21-13-20(14-22(29)26(21)33-17)25-23(30)16-32-27(35-25)34-24-6-5-19(15-31-24)18-7-11-36(2)12-8-18/h5-6,13-16,18H,3-4,7-12H2,1-2H3,(H,31,32,34,35)
• InChIKey: AEFFENQISAXIKE-UHFFFAOYSA-N
• SMILES: CC1=NC2=C(C13CCCC3)C=C(C=C2F)C4=NC(=NC=C4F)NC5=NC=C(C=C5)C6CCN(CC6)C

CDK4/6/1 Inhibitor（Cat No.:I019885）is a potent compound that inhibits the activity of cyclin-dependent kinases 4, 6, and 1, which are crucial for regulating cell cycle progression. By blocking these kinases, this inhibitor disrupts the G1/S transition in the cell cycle, leading to cell growth arrest and potential apoptosis. It is widely studied in cancer research due to its ability to halt the proliferation of cancer cells. This inhibitor is an important tool for exploring targeted cancer therapies and advancing drug development. Ideal for biochemical and pharmaceutical research.

Reference

[1]. Yin L, et al. A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy. Eur J Med Chem. 2018 Jan 20;144:1-28.