CDK5 inhibitor 20-223

• CAT Number: I015540
• CAS Number: 865317-30-2
• Molecular Formula: C₁₉H₁₉N₃O
• Molecular Weight: 305.37
• Purity: ≥95%
• Target: CDK
• Storage: Store at -20°C
• IUPAC Name: N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-naphthalen-2-ylacetamide
• InChI: InChI=1S/C19H19N3O/c23-19(20-18-12-17(21-22-18)15-6-3-7-15)11-13-8-9-14-4-1-2-5-16(14)10-13/h1-2,4-5,8-10,12,15H,3,6-7,11H2,(H2,20,21,22,23)
• InChIKey: AGVIDDQHAQSPIZ-UHFFFAOYSA-N
• SMILES: C1CC(C1)C2=CC(=NN2)NC(=O)CC3=CC4=CC=CC=C4C=C3

CDK5 inhibitor 20-223（Cat No.:I015540）is a potent inhibitor of both CDK2 and CDK5, with IC50 values of 6.0 and 8.8 nM, respectively. This compound shows promise for studying colorectal cancer (CRC), a type of cancer affecting the colon and rectum. By targeting CDK2 and CDK5, CDK5 inhibitor 20-223 has the potential to interfere with cell cycle regulation and signaling pathways implicated in CRC, making it a valuable tool for further research in this field.

Reference

[1]. Caroline M Robb, et al. Characterization of CDK(5) Inhibitor, 20-223 (Aka CP668863) for Colorectal Cancer Therapy. Oncotarget. 2017 Dec 28;9(4):5216-5232.