CDK8-IN-11

• CAT Number: I042818
• CAS Number: 2839338-28-0
• Molecular Formula: C19H15F3N4O2
• Molecular Weight: 388.34
• Purity: ≥95%
• Synonyms: 1-[4-(6-aminopyridin-3-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
• InChI: InChI=1S/C19H15F3N4O2/c20-19(21,22)12-2-1-3-14(10-12)26-18(27)25-13-4-6-15(7-5-13)28-16-8-9-17(23)24-11-16/h1-11H,(H2,23,24)(H2,25,26,27)
• InChIKey: MBIXOXMOHXFUFZ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)NC(=O)NC2=CC=C(C=C2)OC3=CN=C(C=C3)N)C(F)(F)F

CDK8-IN-11（Cat No.:I042818）is a small molecule inhibitor targeting cyclin-dependent kinase 8 (CDK8), a key component of the Mediator complex that regulates gene transcription. CDK8 is involved in controlling gene expression related to cell growth, differentiation, and cancer progression. By inhibiting CDK8, CDK8-IN-11 aims to modulate transcriptional processes and suppress the expression of genes that contribute to tumorigenesis. This compound is being explored for its potential in treating various cancers, particularly those driven by aberrant transcriptional regulation. Ongoing research focuses on evaluating its safety, efficacy, and therapeutic potential in clinical applications.