CDK9-IN-10

• CAT Number: I016340
• CAS Number: 3542-63-0
• Molecular Formula: C22H16O5
• Molecular Weight: 360.36
• Purity: ≥95%
• Synonyms: 5,8-dihydroxy-2-phenyl-7-phenylmethoxychromen-4-one
• InChI: InChI=1S/C22H16O5/c23-16-11-18(15-9-5-2-6-10-15)27-22-20(16)17(24)12-19(21(22)25)26-13-14-7-3-1-4-8-14/h1-12,24-25H,13H2
• InChIKey: OQHAZMRRNANBMN-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)COC2=C(C3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=CC=C4)O

CDK9-IN-10 is a potent CDK9 inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811)[1].

Reference

[1]. Bian J, et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
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