CDK9-IN-13

• CAT Number: I044094
• CAS Number: 2768712-71-4
• Molecular Formula: C27H35N5O2
• Molecular Weight: 461.60
• Purity: ≥95%
• Synonyms: 5-[2-[1-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-propan-2-ylpyridin-2-one
• InChI: InChI=1S/C27H35N5O2/c1-19(2)32-17-21(6-7-25(32)33)22-8-11-28-27-23(22)16-24(29-27)20-9-14-30(15-10-20)18-26(34)31-12-4-3-5-13-31/h6-8,11,16-17,19-20H,3-5,9-10,12-15,18H2,1-2H3,(H,28,29)
• InChIKey: GLYHKPNATCXTDU-UHFFFAOYSA-N
• SMILES: CC(C)N1C=C(C=CC1=O)C2=C3C=C(NC3=NC=C2)C4CCN(CC4)CC(=O)N5CCCCC5

CDK9-IN-13 (compound 38) is potent and selective CDK9 inhibitor, with an IC50 of <3 nM. CDK9-IN-13 exhibits short half-lives in rodents[1].

Reference

[1]. Barlaam B, et, al. Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J Med Chem. 2021 Oct 28;64(20):15189-15213.
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