For research use only. Not for therapeutic Use.
<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">CDPPB (CAS 781652-57-1) is a pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic mGluR-5 (glutamate receptor subtype 5). This also exerts anti-psychotic-like effects. It is reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR-5 cells (EC<sub style="color: rgb(51, 51, 51); font-family: openSans, arial, sans-serif; box-sizing: border-box; line-height: 1;">50</sub> = 10 nM. It does not potentiate the activity of other glutamate receptors.</span></span></span>
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| CAS Number | 781652-57-1 |
| Synonyms | 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide |
| Molecular Formula | C23H16N4O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at +4C |
| IUPAC Name | 3-cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide |
| InChI | InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28) |
| InChIKey | BKUIZWILNWHFHD-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4 |
| Reference | <span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">1.Lindsley, Craig W., et al. "Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1, 3-diphenyl-1 H-pyrazol-5-yl) benzamides that potentiate receptor function in vivo." <i style="font-family: Arial, sans-serif; font-size: 13px;">Journal of medicinal chemistry</i> 47.24 (2004): 5825-5828.<br /> |
