Ceapin-A7

• CAT Number: I024299
• CAS Number: 2323027-38-7
• Molecular Formula: C20H12F6N4O3
• Molecular Weight: 470.33
• Purity: 98%
• Synonyms: Ceapin-A7; Ceapin A7; CP-A7; CPA7; CP A7
• Target: ATF6
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: -20°C
• IUPAC Name: N-(1-(2,4-bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-5-(furan-2-yl)isoxazole-3-carboxamide
• InChI: InChI=1S/C20H12F6N4O3/c21-19(22,23)12-4-3-11(14(6-12)20(24,25)26)9-30-10-13(8-27-30)28-18(31)15-7-17(33-29-15)16-2-1-5-32-16/h1-8,10H,9H2,(H,28,31)
• InChIKey: UJTDYOXTXGBHEG-UHFFFAOYSA-N
• SMILES: O=C(C1=NOC(C2=CC=CO2)=C1)NC3=CN(CC4=CC=C(C(F)(F)F)C=C4C(F)(F)F)N=C3

Ceapin-A7（Cat No.: I024299）, is a selective inhibitor specifically targeting the ATF6α signaling pathway associated with endoplasmic reticulum (ER) stress. It effectively blocks this pathway with an IC50 of 0.59 μM. Ceapin-A7 serves as a valuable tool for investigating the mechanisms by which ATF6α promotes cell activation, shedding light on its role in various physiological and pathological settings. Its use can provide insights into ER stress-related cellular responses and may have implications for understanding and potentially intervening in conditions where ER stress plays a significant role, such as certain neurodegenerative diseases and metabolic disorders.