For research use only. Not for therapeutic Use.
Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].
Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1].
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1].
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].
| Catalog Number | I044812 |
| CAS Number | 52811-37-7 |
| Synonyms | (2,5-dihydroxy-4-methoxyphenyl)-phenylmethanone |
| Molecular Formula | C14H12O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H12O4/c1-18-13-8-11(15)10(7-12(13)16)14(17)9-5-3-2-4-6-9/h2-8,15-16H,1H3 |
| InChIKey | NFJVELXCUBWAFL-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C(=C1)O)C(=O)C2=CC=CC=C2)O |
| Reference | [1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242. |
