For research use only. Not for therapeutic Use.
Cedrol(Cat No.:I014289)is a naturally occurring sesquiterpene alcohol found in the essential oils of cedarwood and other coniferous trees. Known for its pleasant, woody aroma, cedrol is widely used in perfumery and aromatherapy for its calming effects. It has also attracted interest in research for potential therapeutic properties, including anti-inflammatory, antimicrobial, and sedative effects, making it useful in alternative medicine. Cedrol’s unique chemical profile makes it valuable in studying plant-based bioactive compounds and their applications in wellness, relaxation, and potential medicinal benefits.
Catalog Number | I014289 |
CAS Number | 77-53-2 |
Synonyms | Cedrol; AI3-02178; Eudesmol;(3R-(3alpha,3Abeta,6alpha,7beta,8aalpha))-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol |
Molecular Formula | C15H26O |
Purity | ≥95% |
Target | Anti-infection |
Solubility | Soluble in DMSO |
IUPAC Name | (1S,2R,5S,7R,8R)-2,6,6,8-tetramethyltricyclo[5.3.1.01,5]undecan-8-ol |
InChI | InChI=1S/C15H26O/c1-10-5-6-11-13(2,3)12-9-15(10,11)8-7-14(12,4)16/h10-12,16H,5-9H2,1-4H3/t10-,11+,12-,14-,15+/m1/s1 |
InChIKey | SVURIXNDRWRAFU-OGMFBOKVSA-N |
SMILES | C[C@@H]1CC[C@@H]2[C@]13CC[C@@]([C@H](C3)C2(C)C)(C)O |
Reference | </br>1: Jin MH, Park SG, Hwang YL, Lee MH, Jeong NJ, Roh SS, Lee Y, Kim CD, Lee JH. Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. Ann Dermatol. 2012 Feb;24(1):16-21. doi: 10.5021/ad.2012.24.1.16. Epub 2012 Feb 2. PubMed PMID: 22363150; PubMed Central PMCID: PMC3283845.</br>2: Jeong HU, Kwon SS, Kong TY, Kim JH, Lee HS. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77(22-24):1522-32. doi: 10.1080/15287394.2014.955906. PubMed PMID: 25343299.</br>3: Kiran I, Durceylan Z, Kirimer N, Baser KH, Noma Y, Demirci F. Biotransformation of alpha-cedrol and caryophyllene oxide by the fungus Neurospora crassa. Nat Prod Commun. 2010 Apr;5(4):515-8. PubMed PMID: 20433062.</br>4: Hori E, Shojaku H, Watanabe N, Kawasaki Y, Suzuki M, de Araujo MF, Nagashima Y, Yada Y, Ono T, Nishijo H. Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects. Auton Neurosci. 2012 May 21;168(1-2):88-92. doi: 10.1016/j.autneu.2012.01.010. Epub 2012 Feb 15. PubMed PMID: 22341589.</br>5: Dayawansa S, Umeno K, Takakura H, Hori E, Tabuchi E, Nagashima Y, Oosu H, Yada Y, Suzuki T, Ono T, Nishijo H. Autonomic responses during inhalation of natural fragrance of Cedrol in humans. Auton Neurosci. 2003 Oct 31;108(1-2):79-86. PubMed PMID: 14614968.</br>6: Collins DO, Reese PB. Biotransformation of cedrol by Curvularia lunata ATCC 12017. Phytochemistry. 2001 Mar;56(5):417-21. PubMed PMID: 11261573.</br>7: Lindh JM, Okal MN, Herrera-Varela M, Borg-Karlson AK, Torto B, Lindsay SW, Fillinger U. Discovery of an oviposition attractant for gravid malaria vectors of the Anopheles gambiae species complex. Malar J. 2015 Mar 20;14:119. doi: 10.1186/s12936-015-0636-0. PubMed PMID: 25885703; PubMed Central PMCID: PMC4404675.</br>8: Umeno K, Hori E, Tsubota M, Shojaku H, Miwa T, Nagashima Y, Yada Y, Suzuki T, Ono T, Nishijo H. Effects of direct cedrol inhalation into the lower airway on autonomic nervous activity in totally laryngectomized subjects. Br J Clin Pharmacol. 2008 Feb;65(2):188-96. Epub 2007 Oct 22. PubMed PMID: 17953722; PubMed Central PMCID: PMC2291227.</br>9: Kagawa D, Jokura H, Ochiai R, Tokimitsu I, Tsubone H. The sedative effects and mechanism of action of cedrol inhalation with behavioral pharmacological evaluation. Planta Med. 2003 Jul;69(7):637-41. PubMed PMID: 12898420.</br>10: Zhang Y, Han L, Chen SS, Guan J, Qu FZ, Zhao YQ. Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis. Biomed Pharmacother. 2016 Oct;83:641-647. doi: 10.1016/j.biopha.2016.07.022. Epub 2016 Jul 25. PubMed PMID: 27459121.</br>11: Su YC, Hsu KP, Wang EI, Ho CL. Composition, anticancer, and antimicrobial activities in vitro of the heartwood essential oil of Cunninghamia lanceolata var. konishii from Taiwan. Nat Prod Commun. 2012 Sep;7(9):1245-7. PubMed PMID: 23074921.</br>12: Green JC, Pettus TR. An oxidative dearomatization-induced [5 + 2] cascade enabling the syntheses of α-cedrene, α-pipitzol, and sec-cedrenol. J Am Chem Soc. 2011 Feb 9;133(5):1603-8. doi: 10.1021/ja109925g. Epub 2010 Dec 31. PubMed PMID: 21194216.</br>13: Mercke P, Crock J, Croteau R, Brodelius PE. Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L. Arch Biochem Biophys. 1999 Sep 15;369(2):213-22. PubMed PMID: 10486140.</br>14: Eller FJ, Vander Meer RK, Behle RW, Flor-Weiler LB, Palmquist DE. Bioactivity of cedarwood oil and cedrol against arthropod pests. Environ Entomol. 2014 Jun;43(3):762-6. doi: 10.1603/EN13270. Epub 2014 Mar 31. 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Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice. Environ Toxicol Pharmacol. 2016 Sep;46:270-276. doi: 10.1016/j.etap.2016.07.020. Epub 2016 Jul 30. PubMed PMID: 27522546.</br>20: Song WF, Liao MJ, Luo SY. [Analyze on chemical compositions of Dalbergia odorifera essential oils extracted by CO2-supercritical-fluid-extraction and steam distillation extraction]. Zhong Yao Cai. 2011 Nov;34(11):1725-7. Chinese. PubMed PMID: 22506398.</br></br> |