Cefacetrile

• CAT Number: R047719
• CAS Number: 10206-21-0
• Molecular Formula: C13H13N3O6S
• Molecular Weight: 339.32
• Purity: ≥95%
• Synonyms: (6R,7R)-3-[(Acetyloxy)methyl]-7-[(2-cyanoacetyl)amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; 7-(2-Cyanoacetamido)-3-(hydroxymethyl)-8-oxo-5-thia-?-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Acetate (Ester); 7-Cyanoacetamido
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: (6R,7R)-3-(acetyloxymethyl)-7-[(2-cyanoacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• InChI: InChI=1S/C13H13N3O6S/c1-6(17)22-4-7-5-23-12-9(15-8(18)2-3-14)11(19)16(12)10(7)13(20)21/h9,12H,2,4-5H2,1H3,(H,15,18)(H,20,21)/t9-,12-/m1/s1
• InChIKey: RRYMAQUWDLIUPV-BXKDBHETSA-N
• SMILES: CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)CC#N)SC1)C(=O)O

Cefacetrile（Cat No.:R047719）is a broad-spectrum cephalosporin antibiotic used for the treatment of various bacterial infections. It is effective against both Gram-positive and Gram-negative organisms, including staphylococci, streptococci, and certain enterobacteria. Cefacetrile works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is commonly prescribed for respiratory, urinary tract, and skin infections. Administered via intravenous or intramuscular injection, cefacetrile demonstrates high stability in the presence of β-lactamases, making it a reliable option in resistant bacterial strains. It is generally well-tolerated with minimal side effects.

Reference

1:[Stability of sulbenicillin and cefacetrile in bile (author/'s transl)]. Yoshida M, Nonoshita Y, Saito S, Hyon U, Henmi T.Jpn J Antibiot. 1980 Apr;33(4):472-7. Japanese. PMID: 7411851
2:[In vitro and in vivo antibacterial activity of combined flucloxacillin-cefacetrile (Flunicef)]. Venturini AP, Stanzani L, Mantovani V, Mascellani G.G Ital Chemioter. 1979 Jan-Dec;26(1-2):153-8. Italian. No abstract available. PMID: 554805
3:[Serum and joint levels of cefacetrile during its administration for septic arthritis]. Blanc CH, Meyer-Brunot HG, Tosch W, Schelling JL.Schweiz Med Wochenschr. 1978 Jul 1;108(26):988-94. French. PMID: 663591
4:[A clinical study of cefacetrile in the treatment for orthopedic infections (author/'s transl)]. Oto T, Yoshida M, Ueno H, Nishikawa M, Hayashi R.Jpn J Antibiot. 1977 Jul;30(7):484-7. Japanese. No abstract available. PMID: 909136