For research use only. Not for therapeutic Use.
Cefadroxil（Cat No.:I003787）is a first-generation cephalosporin antibiotic used to treat a variety of bacterial infections, including those affecting the skin, throat, and urinary tract. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death, particularly effective against certain Gram-positive and Gram-negative bacteria. Cefadroxil’s oral formulation offers high bioavailability, allowing for convenient dosing in outpatient settings. Its stability and broad-spectrum efficacy make it a reliable option for treating common infections, especially in patients needing a cephalosporin alternative to penicillin-based antibiotics.
| Catalog Number | I003787 |
| CAS Number | 50370-12-2 |
| Molecular Formula | C16H17N3O5S |
| Purity | ≥95% |
| Solubility | 10 mM in H2O, DMSO: ＜ 4.4 mg/mL |
| Storage | Store at -20℃ |
| IUPAC Name | (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| InChI | InChI=1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1 |
| InChIKey | BOEGTKLJZSQCCD-UEKVPHQBSA-N |
| SMILES | CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O |
| Reference | </br>1:Stevens-Johnson syndrome/toxic epidermal necrolysis caused by cefadroxil in a cat. Sartori R, Colombo S.JFMS Open Rep. 2016 Jun 6;2(1):2055116916653616. doi: 10.1177/2055116916653616. eCollection 2016 Jan-Jun. PMID: 28491426 Free PMC Article</br>2:Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study. Chen X, Keep RF, Liang Y, Zhu HJ, Hammarlund-Udenaes M, Hu Y, Smith DE.Biochem Pharmacol. 2017 May 1;131:89-97. doi: 10.1016/j.bcp.2017.02.005. Epub 2017 Feb 10. PMID: 28192085 </br>3:Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Song F, Hu Y, Jiang H, Smith DE.Drug Metab Dispos. 2017 Feb;45(2):130-136. doi: 10.1124/dmd.116.073320. Epub 2016 Nov 11. PMID: 27836942 </br>4:Characteristics, Properties and Analytical Methods of Cefadroxil: A Review. de Marco BA, Salgado HR.Crit Rev Anal Chem. 2017 Mar 4;47(2):93-98. doi: 10.1080/10408347.2016.1219649. Epub 2016 Aug 5. Review. PMID: 27494757 </br>5:Why isn/’t cefadroxil used more often? Corson AH, Myers BE, Dinges WL.Am J Health Syst Pharm. 2016 Jun 1;73(11):754-5. doi: 10.2146/ajhp150841. No abstract available. PMID: 27208060 </br>6:Comparative bioavailability and pharmacokinetic study of Cefadroxil capsules in male healthy volunteers of Pakistan. Rahim N, Naqvi SB, Alam M, Rasheed A, Khalique UA.Pak J Pharm Sci. 2016 Mar;29(2):453-9. PMID: 27087092 </br>7:Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice. Hu Y, Smith DE.Biochem Pharmacol. 2016 May 1;107:81-90. doi: 10.1016/j.bcp.2016.03.008. Epub 2016 Mar 12. PMID: 26979860 Free PMC Article</br>8:Population pharmacokinetic modeling of cefadroxil renal transport in wild-type and Pept2 knockout mice. Xie Y, Shen H, Hu Y, Feng MR, Smith DE.Xenobiotica. 2016;46(4):342-9. doi: 10.3109/00498254.2015.1080881. Epub 2015 Sep 15. PMID: 26372256 Free PMC Article</br>9:Determination of Cefadroxil in Tablet/Capsule formulations by a validated Reverse Phase High Performance Liquid Chromatographic method. Rahim N, Naqvi SB, Shakeel S, Iffat W, Muhammad IN.Pak J Pharm Sci. 2015 Jul;28(4):1345-9. PMID: 26142506 </br>10:Effect of transporter inhibition on the distribution of cefadroxil in rat brain. Chen X, Loryan I, Payan M, Keep RF, Smith DE, Hammarlund-Udenaes M.Fluids Barriers CNS. 2014 Nov 14;11(1):25. doi: 10.1186/2045-8118-11-25. eCollection 2014. PMID: 25414790 Free PMC Article |
