Cefaloglycin

• CAT Number: I005917
• CAS Number: 3577-01-3
• Molecular Formula: C18H19N3O6S
• Molecular Weight: 405.42
• Purity: ≥95%
• Synonyms: Cefaloglycin; cephaloglycin. Kafocin, Kefglycin, Lilly 39435;(6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Target: Bacterial
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: (6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• InChI: InChI=1S/C18H19N3O6S/c1-9(22)27-7-11-8-28-17-13(16(24)21(17)14(11)18(25)26)20-15(23)12(19)10-5-3-2-4-6-10/h2-6,12-13,17H,7-8,19H2,1H3,(H,20,23)(H,25,26)/t12-,13-,17-/m1/s1
• InChIKey: FUBBGQLTSCSAON-PBFPGSCMSA-N
• SMILES: CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)SC1)C(=O)O

Cefaloglycin（Cat No.:I005917）is a broad-spectrum, semi-synthetic cephalosporin antibiotic used in the treatment of bacterial infections. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death. Cefaloglycin is particularly effective against gram-positive bacteria and some gram-negative organisms. It is commonly used in the treatment of respiratory, urinary tract, and skin infections. The compound’s stability against β-lactamase enzymes enhances its efficacy in fighting resistant bacterial strains. Due to its limited absorption in the gastrointestinal tract, Cefaloglycin is typically administered via injection or intravenous infusion.

Reference

1: Tune BM, Fravert D, Hsu CY. Oxidative and mitochondrial toxic effects of cephalosporin antibiotics in the kidney. A comparative study of cephaloridine and cephaloglycin. Biochem Pharmacol. 1989 Mar 1;38(5):795-802. PubMed PMID: 2930580.