Cefazolin Sodium

• CAT Number: A000075
• CAS Number: 27164-46-1
• Molecular Formula: C14H13N8O4S3 • Na
• Molecular Weight: 476.50
• Purity: ≥95%
• Synonyms: cefazoline sodium, cephazolin sodium, Ancef
• Target: Antibiotic
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: sodium;(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1
• InChIKey: FLKYBGKDCCEQQM-WYUVZMMLSA-M
• SMILES: CC1=NN=C(S1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]

Cefazolin Sodium（Cat No.:A000075）is a first-generation cephalosporin antibiotic commonly used to treat bacterial infections, including respiratory, urinary, and skin infections. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death, with high efficacy against Gram-positive organisms like Staphylococcus and Streptococcus species. Cefazolin Sodium is often administered via injection due to its rapid onset and strong activity, making it suitable for perioperative prophylaxis to prevent surgical site infections. Its favorable safety profile and broad activity make it a widely utilized option in both hospital and outpatient settings.

Reference

Georgopapadakou, N. H. /Mechanisms of Action of Cephalosporin 3/’-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli./ American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.