For research use only. Not for therapeutic Use.
Cefazolin Sodium（Cat No.:I005919）is a first-generation cephalosporin antibiotic commonly used to treat bacterial infections in the respiratory tract, skin, bones, joints, and urinary tract. It works by inhibiting bacterial cell wall synthesis, leading to cell rupture and death, making it effective against a range of gram-positive bacteria and some gram-negative organisms. Often administered via injection, Cefazolin Sodium is widely used in surgical prophylaxis to prevent postoperative infections. Its rapid action, effectiveness, and safety profile make it a reliable choice in both clinical and hospital settings.
| Catalog Number | I005919 |
| CAS Number | 27164-46-1 (Na+) |
| Synonyms | Cefazolin Sodium; monosodium cephazolin; Cefazolin sodium salt; Sodium cefazolin; Sodium cephazolin; Kefzol; Sodium Cephazolin; Sodium, Cefazolin; Sodium, Cephazolin; Totacef;;sodium;(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7- |
| Molecular Formula | C14H13N8NaO4S3 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | sodium;(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| InChI | InChI=1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1 |
| InChIKey | FLKYBGKDCCEQQM-WYUVZMMLSA-M |
| SMILES | CC1=NN=C(S1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+] |
| Reference | </br>1:Controlled release of cefazolin sodium antibiotic drug from electrospun chitosan-polyethylene oxide nanofibrous Mats. Fazli Y, Shariatinia Z.Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:641-652. doi: 10.1016/j.msec.2016.10.048. Epub 2016 Oct 26. PMID: 27987755 </br>2:Isolation and characterisation of degradation impurities in the cefazolin sodium drug substance. Sivakumar B, Parthasarathy K, Murugan R, Jeyasudha R, Murugan S, Saranghdar RJ.Sci Pharm. 2013 Jun 4;81(4):933-50. doi: 10.3797/scipharm.1304-14. Print 2013 Oct-Dec. PMID: 24482765 Free PMC Article</br>3:Microarc oxidized TiO2 based ceramic coatings combined with cefazolin sodium/chitosan composited drug film on porous titanium for biomedical applications. Wei D, Zhou R, cheng S, Feng W, Li B, Wang Y, Jia D, Zhou Y, Guo H.Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4118-25. doi: 10.1016/j.msec.2013.05.053. Epub 2013 Jun 6. PMID: 23910322 </br>4:Development of a novel chemiluminescence method for the determination of cefazolin sodium in injectable powder and human urine based on a luminol-Cu(III) complex reaction in alkaline medium. Sun H, Wang J, Wang T.Luminescence. 2013 Jul-Aug;28(4):592-6. doi: 10.1002/bio.2398. Epub 2012 Jul 15. PMID: 22807137 </br>5:Stability of cefazolin sodium in polypropylene syringes and polyvinylchloride minibags. Donnelly RF.Can J Hosp Pharm. 2011 Jul;64(4):241-5. PMID: 22479065 Free PMC Article</br>6:Cefazolin-sodium has no adverse effect on fracture healing in an experimental rabbit model. Akkaya S, Nazalı M, Kılıç A, Bir F.Eklem Hastalik Cerrahisi. 2012 Apr;23(1):44-8. PMID: 22448830 Free Article</br>7:The effects of methylprednisolone and cefazolin sodium on antioxidant status in experimentally induced maxillary sinusitis. Yoruk O, Ucuncu H, Sutbeyaz Y, Aktan B, Gur FO.Acta Otolaryngol. 2009 Oct;129(10):1101-5. doi: 10.1080/00016480802552584. PMID: 19031299 </br>8:Potassium permanganate-glyoxal chemiluminescence system for flow injection analysis of cephalosporin antibiotics: cefalexin, cefadroxil, and cefazolin sodium in pharmaceutical preparations. Sun Y, Tang Y, Yao H, Zheng X.Talanta. 2004 Sep 8;64(1):156-9. doi: 10.1016/j.talanta.2004.02.012. PMID: 18969582 </br>9:Radiosensitivity study of cefazolin sodium. Crucq AS, Slegers C, Deridder V, Tilquin B.Talanta. 2000 Aug 16;52(5):873-7. PMID: 18968047 </br>10:[Physical and chemical characteristics of a new cefazolin sodium hydrate crystal]. Hu CQ, Yin LH, Liang YN.Yao Xue Xue Bao. 2008 Aug;43(8):868-72. Chinese. PMID: 18956782 |
