Cefdinir

For research use only. Not for therapeutic Use.

  • CAT Number: A000338
  • CAS Number: 91832-40-5
  • Molecular Formula: C14H13N5O5S2
  • Molecular Weight: 395.40
  • Purity: ≥95%
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Cefdinir(Cat No.:A000338)is a third-generation oral cephalosporin antibiotic effective against a broad range of Gram-positive and Gram-negative bacteria. It works by inhibiting bacterial cell wall synthesis, causing cell death, and is commonly prescribed for respiratory tract infections, such as sinusitis, bronchitis, and pneumonia, as well as skin infections. Cefdinir’s resistance to many beta-lactamases makes it suitable for treating infections caused by resistant bacterial strains. Known for its favorable safety profile and ease of administration, cefdinir is a reliable choice in outpatient settings for bacterial infection management.


Catalog Number A000338
CAS Number 91832-40-5
Synonyms

91832-40-5; Omnicef; Cefdinirum; CFDN; Cefdinyl

Molecular Formula C14H13N5O5S2
Purity ≥95%
Target Antibiotic
Solubility >19.6mg/mL in DMSO
Storage -20°C
IUPAC Name (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChI InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
InChIKey RTXOFQZKPXMALH-GHXIOONMSA-N
SMILES C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\O)/C3=CSC(=N3)N)SC1)C(=O)O
Reference

1: Cho HJ, Jee JP, Kang JY, Shin DY, Choi HG, Maeng HJ, Cho KH. Cefdinir Solid
Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility,
Dissolution, and Bioavailability in Rats. Molecules. 2017 Feb 13;22(2). pii:
E280. doi: 10.3390/molecules22020280. PubMed PMID: 28208830.
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2: Kaul M, Mark L, Parhi AK, LaVoie EJ, Pilch DS. Combining the FtsZ-Targeting
Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the
Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4290-6. doi: 10.1128/AAC.00613-16.
Print 2016 Jul. PubMed PMID: 27161635; PubMed Central PMCID: PMC4914665.
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3: Wang C, Li J, Feng YC, Liu Y, Hu CQ. [Construction of the quantitative
structure retention relationship of cefdinir related substances]. Yao Xue Xue
Bao. 2015 Sep;50(9):1161-6. Chinese. PubMed PMID: 26757554.
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4: Chen Z, Bi X, Li J, Tang Y, Fan G, Sun D. Application and optimization of
organic-inorganic hybrid monolithic capillary electrochromatography for in vivo
cefdinir determination with microdialysis. J Sep Sci. 2016 Jan;39(2):440-9. doi:
10.1002/jssc.201500817. Epub 2015 Dec 11. PubMed PMID: 26549514.
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5: Sawant KK, Patel MH, Patel K. Cefdinir nanosuspension for improved oral
bioavailability by media milling technique: formulation, characterization and in
vitro-in vivo evaluations. Drug Dev Ind Pharm. 2016;42(5):758-68. doi:
10.3109/03639045.2015.1104344. Epub 2015 Nov 7. PubMed PMID: 26548349.
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6: Abou-Taleb NH, El-Wasseef DR, El-Sherbiny DT, El-Ashry SM. Optimizing the
spectrofluorimetric determination of cefdinir through a Taguchi experimental
design approach. Luminescence. 2016 May;31(3):856-64. doi: 10.1002/bio.3042. Epub
2015 Oct 12. PubMed PMID: 26456088.
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7: Liu L, Cheng F. [Analysis of the interaction between cefdinir and bovine serum
albumin by spectrometry]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015
Sep;40(9):979-86. doi: 10.11817/j.issn.1672-7347.2015.09.006. Chinese. PubMed
PMID: 26408617.
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8: Selvi A, Das D, Das N. Potentiality of yeast Candida sp. SMN04 for degradation
of cefdinir, a cephalosporin antibiotic: kinetics, enzyme analysis and
biodegradation pathway. Environ Technol. 2015;36(24):3112-24. doi:
10.1080/09593330.2015.1054318. Epub 2015 Jun 17. PubMed PMID: 26000889.

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9: Ta&#351;demir &#304;H. Electrochemistry and determination of cefdinir by voltammetric
and computational approaches. J Food Drug Anal. 2014 Dec;22(4):527-536. doi:
10.1016/j.jfda.2014.04.003. Epub 2014 May 22. PubMed PMID: 28911470.
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10: Murphy TK, Parker-Athill EC, Lewin AB, Storch EA, Mutch PJ. Cefdinir for
recent-onset pediatric neuropsychiatric disorders: a pilot randomized trial. J
Child Adolesc Psychopharmacol. 2015 Feb;25(1):57-64. doi: 10.1089/cap.2014.0010.
Epub 2014 Oct 9. PubMed PMID: 25299463; PubMed Central PMCID: PMC4340343.

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