Cefditoren (Pivoxil)

• CAT Number: A000484
• CAS Number: 117467-28-4
• Purity: ≥95%
• Synonyms: 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C25H28N6O7S3/c1-12-15(41-10-27-12)7-6-13-8-39-21-17(29-19(32)16(30-36-5)14-9-40-24(26)28-14)20(33)31(21)18(13)22(34)37-11-38-23(35)25(2,3)4/h6-7,9-10,17,21H,8,11H2,1-5H3,(H2,26,28)(H,29,32)/b7-6-,30-16-/t17-,21-/m1/s1
• InChIKey: AFZFFLVORLEPPO-UVYJNCLZSA-N
• SMILES: CC1=C(SC=N1)C=CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)OCOC(=O)C(C)(C)C

Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections[1][2].
Cefditoren (Pivoxil) shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis[1].

Organism
MIC50 (mg/L)
MIC90 (mg/L)
susceptible (%)

Gram-positive organisms

Streptococcus pneumoniae(untyped)a
0.015-0.25
0.12-1

PS
≤0.008-0.03
0.015-0.25
99-100

PI
0.06-0.5
0.25-0.5
94-100

PR
0.25-1
0.5-2
7-100

S. pyogenes
≤0.008-0.03
0.015-0.03
100

Staphylococcus aureus (MS)
0.12-0.5
0.5-1
50-100

Gram-negative organisms

Haemophilus
≤0.008-≤0.03
0.015-0.13

influenzae (untyped)b

β-Lactamase +
≤0.008-0.03
0.015-0.06
100

β-Lactamase –
≤0.008-0.03
0.015-0.06
100

H. parainfluenzaeb
≤0.03
0.06

Moraxella
0.03-0.5
0.25-1
96

catarrhalis (untyped)b