Cefepime

• CAT Number: R004346
• CAS Number: 88040-23-7
• Molecular Formula: C19H24N6O5S2
• Molecular Weight: 480.56
• Purity: ≥95%
• Target: Penicillin-binding protein (PBP)
• Storage: -20°C
• IUPAC Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
• InChIKey: HVFLCNVBZFFHBT-ZKDACBOMSA-N
• SMILES: C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-]

Cefepime（Cat No.:R004346）is a fourth-generation cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. It works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to cell lysis and death. Cefepime is commonly used to treat severe infections, such as pneumonia, urinary tract infections, and sepsis, especially in hospitalized patients. Its stability against β-lactamases enhances its efficacy against resistant strains. Cefepime is a critical tool in both clinical practice and research on antibiotic resistance and bacterial pathogenesis.

Reference

Georgopapadakou, N. H. /Mechanisms of Action of Cephalosporin 3/’-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli./ American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.