Cefepime

• CAT Number: R004346
• CAS Number: 88040-23-7
• Molecular Formula: C19H24N6O5S2
• Molecular Weight: 480.56
• Purity: ≥95%
• Storage: -20°C

Cefepime is a fourth generation cephalosporin antibiotic.Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Interestingly, cefepime is resistant to various β-lactamases encoded by otherwise resistant β-lactam bacteria strains.

Reference

Georgopapadakou, N. H. /Mechanisms of Action of Cephalosporin 3/’-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli./ American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.