Cefmenoxime hydrochloride

• CAT Number: I004805
• CAS Number: 75738-58-8
• Molecular Formula: C16H17N9O5S3 . 1/2 HCl
• Molecular Weight: 529.79
• Purity: ≥95%
• Target: Antibiotic
• Solubility: DMSO: 8 mg/mL
• Storage: Store at 4°C
• IUPAC Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrochloride
• InChI: InChI=1S/2C16H17N9O5S3.ClH/c2*1-24-16(20-22-23-24)33-4-6-3-31-13-9(12(27)25(13)10(6)14(28)29)19-11(26)8(21-30-2)7-5-32-15(17)18-7;/h2*5,9,13H,3-4H2,1-2H3,(H2,17,18)(H,19,26)(H,28,29);1H/b2*21-8-;/t2*9-,13-;/m11./s1
• InChIKey: MPTNDTIREFCQLK-UNVJPQNDSA-N
• SMILES: CN1N=NN=C1SCC2=C(N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)C(=O)O.CN1N=NN=C1SCC2=C(N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)C(=O)O.Cl

Cefmenoxime hydrochloride（Cat No.:I004805）is a third-generation cephalosporin antibiotic. It belongs to the class of beta-lactam antibiotics and is effective against a wide range of bacteria, including both Gram-positive and Gram-negative strains. Cefmenoxime works by inhibiting bacterial cell wall synthesis, leading to cell death. As a third-generation cephalosporin, it has an extended spectrum of activity and increased resistance to beta-lactamases. Cefmenoxime hydrochloride is commonly used in the treatment of various infections, including respiratory, urinary tract, skin, and soft tissue infections, among others.

Reference

1:Int J Pharm Compd. 1998 Jul-Aug;2(4):318-21. Compatibility and stability of ranitidine hydrochloride with six cephalosporins during simulated y-site administration.Inagaki K,Kambara M,Mizuno M,Okuda J,Gill MA,Nishida M, PMID: 23989642 Abstract: The purpose of this project was to determine the visual compatibility and stability of ranitidine hydrochloride in admixtures during simulated Y-site administration with six individual cephalosporins: ceftizoxime sodium, cefuzonam sodium, cefoperazone sodium, cefmenoxime hydrochloride, moxalactam disodium and flomoxef sodium. Dilutions of ranitidine hydrochloride 1 mg (as the free base)/mL were prepared in 0.9% sodium chloride injection. Two milliliters of the ranitidine solution (1mg/mL) was mixed with 2mL of each cephalosporin (20 mg/ml) in 10 mL glass test tubes. Concentrations of each drug were determined by stability-indicationg high-performance liquid chromatographic assay methods following zero, one, two, and four hours after mixing. All six cephalosporins retained greater than 95% of their original concentrations for four hours in the admixture with ranitidine. Ranitidine retained greater than 95% of its original concentration for four hours in the admixture with four of the tested cephalosporins and apporximately 90% with moxalactam and flomoxef. Solutions containing ranitidine may be coadministered with solutions either ceftizoxime, cefuzonam, cefoperazone or cefmenoxime via Y-injection site over four hours. While the ranitidine concentration may be reduced to near 90% after four hours with moxalactam and flomoxef, the tested antibiotics were not affected in the presence of ranitidine over four hours.